Ghrelin Causes Hyperphagia and Obesity in Rats
نویسندگان
چکیده
منابع مشابه
Ghrelin causes hyperphagia and obesity in rats.
Ghrelin, a circulating growth hormone-releasing peptide derived from the stomach, stimulates food intake. The lowest systemically effective orexigenic dose of ghrelin was investigated and the resulting plasma ghrelin concentration was compared with that during fasting. The lowest dose of ghrelin that produced a significant stimulation of feeding after intraperitoneal injection was 1 nmol. The p...
متن کاملCentral relaxin-3 administration causes hyperphagia in male Wistar rats.
Relaxin-3 (INSL-7) is a recently discovered member of the insulin superfamily. Relaxin-3 mRNA is expressed in the nucleus incertus of the brainstem, which has projections to the hypothalamus. Relaxin-3 binds with high affinity to the LGR7 receptor and to the previously orphan G protein-coupled receptor GPCR135. GPCR135 mRNA is expressed predominantly in the central nervous system, particularly ...
متن کاملRelation between Plasma Levels of Ghrelin and Hyperphagia in Streptozotocin-Induced Diabetes in Male Albino Rats
Background: Ghrelin, a hormone identified in the stomach, is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R) and the peripheral or central administration of ghrelin increases food intake and body weight. Ghrelin release and gene expression are regulated by nutrient flux, such that plasma ghrelin levels increase steadily before meal onset and fall rapidly after food ing...
متن کاملDiet-induced obesity causes ghrelin resistance in reward processing tasks
Diet-induced obesity (DIO) causes ghrelin resistance in hypothalamic Agouti-related peptide (AgRP) neurons. However, ghrelin promotes feeding through actions at both the hypothalamus and mesolimbic dopamine reward pathways. Therefore, we hypothesized that DIO would also establish ghrelin resistance in the ventral tegmental area (VTA), a major site of dopaminergic cell bodies important in reward...
متن کاملFood reward, hyperphagia, and obesity.
Given the unabated obesity problem, there is increasing appreciation of expressions like "my eyes are bigger than my stomach," and recent studies in rodents and humans suggest that dysregulated brain reward pathways may be contributing not only to drug addiction but also to increased intake of palatable foods and ultimately obesity. After describing recent progress in revealing the neural pathw...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Diabetes
سال: 2001
ISSN: 0012-1797,1939-327X
DOI: 10.2337/diabetes.50.11.2540